Study population and setting
Observational data on 1559 individuals with known blood type who had been tested for SARS-CoV-2 were extracted from the New York Presbyterian hospital system. Associations between ABO+Rh blood type and SARS-CoV-2 with: 1) infection status; 2) intubation; and 3) death were examined, adjusting for age, sex, overweight status, diabetes, hypertension, pulmonary diseases, and cardiovascular diseases.
Summary of Main Findings
Among the 1559 individuals tested for SARS-CoV-2, 682 tested positive. Of those who tested positive, a total of 179 were intubated and 80 died. Those in blood group A had higher odds of testing positive for SARS-CoV-2 (OR: 1.34, 95% CI [1.07-1.67], and those in blood groups O (OR: 0.80, 95% CI [0.65-0.99] and AB (OR: 0.56, 95%CI [0.31-0.97] had decreased odds of testing positive, even after adjusting for other risk factors. There were no significant differences found between blood group and the outcomes of intubation or death.
This study improves on methods published in previous studies by comparing those who tested positive and those who tested negative in the same population. The analyses also adjusted for other risk factors.
These data are preliminary and cross-sectional, and it is not possible to determine whether those who were captured in this study are representative of all individuals living in New York, albeit a larger target population. The findings represent preliminary associations and should be further investigated. Larger sample sizes may be needed to examine differences between ABO+Rh group.
This is one of the few studies to investigate the association between blood type and odds of testing positive for SARS-CoV-2, and builds on results from previous studies.
This review was posted on: 9 February 2021