Study population and setting
Investigators sampled 6,904 individuals 12 years or older from three wards in Mumbai, India (Matunga, Chembur West, and Dahisar) to test the positivity rate of IgG antibodies to SARS-CoV-2 infection which would indicate prior infection. Investigators sampled individuals by randomly sampling households and testing one member of a sampled household in order to ensure a representative sample of the surveyed areas. They aimed to compare the seroprevalence of antibodies between slums (i.e. communities of people living on land for which they do not have legal rights) and non-slums. There were 4,202 participants in slums and 2,702 participants in non-slums. Investigators estimated the average prevalence over a two-week period (June 29 to July 14, 2020 in slums and July 3 to July 19, 2020 in non-slums).
Summary of Main Findings
The positive test rate of IgG antibodies in those sampled from slums was 54.1% compared to 16.1% among those in non-slums, for a prevalence difference of 38%. When adjusting for potential test imperfections (i.e. having a sensitivity of 0.90 and a specificity of 1.00) the positive test rate was 58.4% in slums and 17.3% in non-slums.
This study is one of few studies to provide seroprevalence estimates in from Mumbai, India and to compare results between slum and non-slum areas.
The denominator for the seroprevalence was estimated through using 2011 Census data, which may not accurately reflect the current population estimates. Additionally, these data may not be representative to the general Mumbai population if the specific wards are not reflective of Mumbai demographics. Thus, the figures can be an over or underestimation of the prevalence of IgG antibodies among slums or non-slums. The research team couldn’t gain access to all buildings in non-slum areas and therefore some of the participant sampling was out of their control and may not have been random. Additionally, the authors note that participants in non-slums were less willing to participate due to fear of being exposed to the virus when getting tested.
This study shows a significantly higher burden of SARS-CoV-2 exposure among slums compared to non-slums, and thus highlights underpinning issues (e.g. high population density and poor infrastructure) that may contribute to higher infection rates. This has the potential to lead to higher morbidity and mortality in these areas as it would be harder to control transmission.
This review was posted on: 28 October 2020