Study population and setting
24 patients (mean age 64 years; 63% male) with laboratory-confirmed SARS-CoV-2 infection without known travel-related exposure admitted to the ICUs of nine Seattle hospitals from February 24, 2020-March 9, 2020. Patients were followed for at least 14 days.
Summary of Main Findings
Mean duration of symptoms before admission was 7 days. Only 50% presented with measured fever. All patients were admitted for hypoxemic respiratory failure and 75% required mechanical ventilation, often with high plateau and driving pressures. At the time of publication, 50% of patients had died, 30% remained in the hospital (13% receiving mechanical ventilation), and 21% had been discharged.
Provides detailed description of clinical course in a U.S healthcare setting, including laboratory findings, comorbid conditions, radiographic features, and ventilator parameters.
Small number of patients; excluded those <18 years of age. Limited to critically ill patients with COVID-19 who presented to the hospital.
This study provides details relevant for providers caring for critically-ill COVID-19 patients in a high-resource setting with available ventilators. It also provides further data on the clinical course and mortality of critically-ill patients in the United States.